Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, accompanied by intense itching, redness, dryness and scaling. For decades, classical dermatology focused mainly on genetic factors and external relief of symptoms with hormonal ointments, immunosuppressants and emollients. However, modern 4P medicine (personalized, predictive, preventive, patient-centered) has revolutionized the understanding of this disease.