Dermo-balance: how personalized correction of the gut and skin microbiome restores natural beauty and health
Introduction: The New Paradigm of Dermatology and the Concept of 4P Medicine
For many decades, traditional dermatology and aesthetic cosmetology perceived the skin as an isolated organ, and most dermatological problems as local defects. When acne, atopic dermatitis, seborrhea, rosacea or premature wrinkles appeared, the standard treatment algorithm usually came down to external influences: the appointment of antibacterial ointments, alcohol lotions, hormonal creams or aggressive chemical peels.
However, this strategy only masks the external symptoms, usually without eliminating the underlying physiological causes of the disease. Moreover, aggressive external intervention often depletes the epidermis' own protective resources, causing relapses and turning the disease into a chronic form.
Today, global medicine is undergoing a fundamental transformation. At the center of attention for preventive, preventive, personalized, and patient-centered medicine (4P medicine) is the human microbiome—a complex ecosystem of trillions of microorganisms that inhabit our mucous membranes and skin.
It has been scientifically proven that the condition of our skin is a direct reflection of internal microbial and immunological homeostasis. The answer to the request for a new, scientifically based approach to beauty was the comprehensive wellness program “Dermo-balance: microbiome and skin beauty” , developed by the Ukrainian biotechnology company Ediens.
This program combines deep molecular diagnostics, algorithmic data analysis, and two-vector (internal and external) targeted correction of the microbiome.
1. Molecular mechanisms of the Gut-Skin Axis
To understand why even the most expensive external creams are ineffective in chronic rashes, it is necessary to consider the functioning of the anatomical and physiological Gut-Skin Axis .
The gastrointestinal tract and skin share a common evolutionary origin, are densely permeated with nerve endings, blood vessels, and form the largest immunocompetent barriers in our body. The colon contains the majority of all immune cells in the body, and their activity is controlled by the intestinal microbiome.
When dysbiosis occurs in the intestines under the influence of an unbalanced diet, stress, or medication, a whole cascade reaction is triggered:
Mucin depletion and leaky gut syndrome: Beneficial commensal bacteria, deprived of plant fibers, begin to break down the protective mucus of the intestinal wall. The disrupted tight junctions of enterocytes make the intestinal wall permeable to toxic substances.
Metabolic endotoxemia: Components of the cell membranes of pathogenic bacteria — lipopolysaccharides (LPS) — massively penetrate the systemic bloodstream.
Low-Grade Inflammation: Circulating endotoxins in the blood cause activation of immune receptors and massive release of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6).
Dermatological manifestation: Pro-inflammatory cytokines and bacterial metabolites reach the dermis and epidermis through the bloodstream. This disrupts microcirculation, changes the composition of sebum, suppresses local immunity, and provokes the development of inflammatory elements - acne, rosacea, eczema, atopic dermatitis, or couperose.
Thus, it is physiologically impossible to eliminate chronic inflammation on the face without restoring the integrity of the intestinal barrier and normalizing the gastrointestinal microflora.
2. The skin microbiome ecosystem: a deep protective shield
In addition to the intestinal microflora, the skin's own microbiome is of great importance. Our skin is not a sterile surface, but a dynamic biotope, home to hundreds of species of bacteria, fungi, and microscopic mites.
Under normobiosis conditions, commensal bacteria (in particular Staphylococcus epidermidis , Lactobacillus spp., Propionibacterium/Cutibacterium granulosum ) perform vital functions:
Formation of an acid mantle: Bacteria break down sebum lipids to form free fatty acids, maintaining an acidic pH of the skin (4.5–5.5). This acidic environment is detrimental to pathogens.
Synthesis of antimicrobial peptides: Commensals produce natural antibiotic-like substances (bacteriocins) that inhibit the growth of pathogenic Staphylococcus aureus and hyperactive cariogenic or acnegenic strains of Cutibacterium acnes .
Stimulation of regeneration: Beneficial microorganisms participate in the maturation of the epidermal barrier, accelerate the healing of microcracks, and stimulate the secretion of its own hyaluronate and ceramides.
Daily care mistakes — using aggressive gels with harsh surfactants, alcohol-based toners, or thoughtless use of antibacterial soap — wash away this protective lipid-microbial film. Pathogenic strains rapidly colonize the vacated space, causing peeling, irritation, dryness, or, conversely, compensatory hypersecretion of sebum.
3. The impact of nutrition, stress and lifestyle on dermatological status
The skin is an extremely sensitive indicator of our lifestyle. The Dermo-balance program takes into account three key epigenetic factors that influence the state of the microbiome every day:
A. Alimentary factor (nutrition)
A diet high in refined sugars, trans fats, processed sauces, and preservatives causes spikes in insulin and insulin-like growth factor (IGF-1). This stimulates sebaceous gland hypertrophy, making sebum thick and viscous, creating an ideal environment for Cutibacterium acnes to thrive . In addition, a lack of soluble and insoluble fiber deprives gut bacteria of a nutrient substrate for the production of butyrate, a key anti-inflammatory metabolite.
B. Psycho-emotional stress (cortisol axis)
During prolonged stress, the adrenal glands secrete excess cortisol. The stress hormone causes spasm of skin microcapillaries, reduces the production of structural proteins (collagen, elastin, filaggrin) and changes the chemical composition of sebum. Stress suppresses the population of beneficial lactobacilli in the intestines and on the skin, opening the way for inflammation.
B. Circadian disorders and the environmental exposome
Lack of sleep at night disrupts the processes of natural skin regeneration, which occur most intensively from 11:00 p.m. to 4:00 a.m. And ultraviolet radiation and pollution of urban air form free radicals in the epidermis, which oxidize the lipids of the skin barrier.
4. Dermo-balance comprehensive wellness program from Ediens
To break the pathological cycle of chronic dermatological problems, the Ediens scientific team developed the program “Dermo-balance: microbiome and skin beauty” . It is based on 35 years of scientific experience in fundamental research in molecular microbiology and immunology under the leadership of Professor Nadiya Volodymyrivna Boyko.
The Dermo-balance program implements a phased, strictly individualized recovery algorithm based on the principle of 3P medicine.
Stage 1. Advanced molecular genetic diagnostics
The program begins not with a formulaic prescription of drugs, but with a comprehensive examination of the patient's biological material:
In-depth study of skin microbiota : Performed by deep scraping from affected skin areas. The analysis isolates and accurately identifies commensal and opportunistic microorganisms (aerobic and anaerobic biomarkers) to the species level, determining the exact ratio of bacteria and the causal role of a specific strain in the development of inflammation.
Molecular genetic analysis of the gut microbiome (NGS sequencing) : Determines the DNA profile of the gut microbiota, the level of biodiversity, the ratio of major bacterial phyla, and the level of short-chain fatty acids.
Biochemical marker analysis and extended questionnaire : Metabolic indicators, inflammatory markers are assessed, and the patient's lifestyle, eating habits, and current care are analyzed in detail.
Stage 2. Algorithmic processing and personalized nutrition plan
The obtained diagnostic data is uploaded to the proprietary digital platform Ediens. The unique IT algorithm EdiensUniCode (BioQuantum) compares the individual Shift deviations of the patient's microbiome with its own expanded database of interactions between biologically active substances of plants and bacteria.
Based on this, the Microbiome Nutrition Plan (Biocode4U) is created - a personalized diet for 14-28 days. It is calculated on the basis of traditional local and fermented foods, where plant ingredients act as highly precise prebiotics for those beneficial strains of the patient that are in deficiency. This allows you to smoothly eliminate intestinal dysbiosis, stop endotoxemia and nourish the skin from the inside.
Stage 3. Two-vector target correction (Internal and External protection)
The main innovation of the Dermo-balance program is the combination of systemic internal effects on the intestines and direct external effects on the skin microbiome:
Internal Vector: Niche Pharmabiotic “My Beautiful Skin” (Skin Balance)
The patient receives a course of a specialized new generation pharmabiotic "My Beautiful Skin" (Biocode4U: Skin Balance) . The drug contains a highly concentrated composition of live clinically validated author's strains (in particular, Enterococcus faecalis M4-II-I and compatible lactobacteria in an amount of not less than $10^8$ CFU).
The pharmabiotic actively colonizes the intestines, inhibits putrefactive processes, restores the integrity of the mucosal barrier, blocks the entry of toxins into the blood, and inhibits the production of pro-inflammatory cytokines, removing the systemic source of skin inflammation.
External Vector: Personalized Probiotic Cosmetics BioMe Cosmetics
Based on the results of an in-depth analysis of the skin microbiota, Ediens produces an individualized cosmetic product for the patient (original soap with probiotics) :
The soap contains the clinically tested probiotic strain (for example, Lactobacillus bulgaricus A22 ) that has shown maximum inhibitory activity in laboratory conditions against pathogens isolated from a given patient (acne or dermatitis).
The soap is made on a 100% natural plant basis with the addition of softening ingredients (glycerin, honey), without aggressive chemical fragrances or sulfates.
When washed, active probiotic metabolites and bacterial strains instantly suppress pathogenic flora on the face, normalize pH, and restore the skin's natural protective barrier.
Creation of an individual commensal microbiota bank
As part of the program, Ediens offers a unique service — preserving the patient's selected beneficial autoprobiotic strains in a personal cryobank. This allows for the future creation of new personalized cosmetics or the use of one's own bacteria for rapid recovery after antibiotic therapy or severe stress.
Conclusions: Healthy skin is the result of scientific balance
The Ediens Dermo-balance: Microbiome and Skin Beauty program sets a new standard in modern dermatology and aesthetic medicine. It proves that true beauty does not require masking or aggressive chemical interventions.
Combining deep molecular diagnostics, personalized prebiotic nutrition, targeted pharmabiotics for the gut, and customized probiotic facial cosmetics, Dermo-balance addresses the very root cause of dermatological disorders. This allows you to tame acne, dermatitis, and inflammation, restoring smoothness, natural radiance, and youthfulness to the skin at the molecular level!
Short questions and answers (Q&A)
1. How is the condition of the intestine related to the appearance of acne and dermatitis on the face? Answer: The intestine and skin are inextricably linked through the “gut-skin” axis. In intestinal dysbiosis, the protective mucous barrier of the gastrointestinal tract is destroyed, and bacterial toxins (lipopolysaccharides) enter the bloodstream. This causes low-intensity systemic inflammation. Pro-inflammatory cytokines reach the skin through the bloodstream, change the composition of sebum and cause inflammatory elements - acne, dermatitis, rosacea or seborrhea.
2. Why do ordinary antibacterial creams and alcohol-based tonics often worsen the condition of the skin? Answer: Aggressive cosmetics, alcohol and antibiotics destroy not only pathogens, but also the skin's own beneficial commensal microflora ( Staphylococcus epidermidis , lactobacilli). This disrupts the skin's acid mantle (pH) and destroys the epidermal barrier. As a result, the skin loses moisture, becomes unprotected, and pathogenic bacteria multiply even more actively in the vacated place, causing relapse of rashes.
3. What is unique about the personalized BioMe Cosmetics soap from Ediens? Answer: Personalized soap is created based on the results of an in-depth analysis of the skin microbiota of a specific patient. It contains exactly the probiotic strain (for example, Lactobacillus bulgaricus A22 ), which has proven in the laboratory its ability to suppress pathogens isolated from a given person. The soap is made on a 100% natural basis without harsh surfactants and chemical fragrances, gently cleansing the skin and restoring its microbial shield.
4. What is included in the comprehensive Dermo-balance program from Ediens? Answer: The Dermo-balance program includes: (1) in-depth molecular genetic research of the skin and intestinal microbiomes, (2) development of an individual Biocode4U nutrition plan using the EdiensUniCode IT algorithm, (3) a course of internal targeted pharmabiotics “My Beautiful Skin” for intestinal restoration, and (4) creation of individual probiotic cosmetics BioMe Cosmetics for external skin care.
You can learn more about the stages of the program, undergo diagnostics, and order your personal skin health kit on the official page:
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