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Manifesto for the Medicine of the Future: Ediens Scientific Director Professor Nadiya Boyko co-authored a new fundamental book from Springer Nature



The modern healthcare system around the world is experiencing a deep systemic crisis. Traditional "reactive" medicine, which begins to act only after the first clinical symptoms of the disease appear (most often in its late or even irreversible stages), demonstrates its financial and therapeutic inability to combat the pandemic of chronic non-communicable diseases. Obesity, type 2 diabetes, cardiovascular pathologies, neurodegenerative disorders and depression are rapidly "getting younger", affecting millions of working-age people aged 20 and over every year.


To change this alarming trend, the world's scientific elite is uniting efforts around the concept of 3P medicine  (Predictive, Preventive and Personalized Medicine), which shifts the focus of doctors' attention from the process of treating symptoms to identifying individual predisposition to diseases long before their actual manifestation.


An important event marking a new stage in the development of this philosophy at the global level will be the publication of the fundamental scientific work “The  Impact of Lifestyle Medicine on Chronic Disease Prevention, Reversal and Management”. The book is published in the prestigious international series Advances in Predictive, Preventive and Personalised Medicine  of the European Association EPMA  and is published by one of the most respected scientific publishers in the world - Springer Nature .


For Ukraine, this event is a reason for special pride. The international team of authors of the publication includes the founder and scientific director of the Ukrainian biotechnology company Ediens, head of the Department of Microbiology, Immunology and Virology of Uzhhorod National University, Doctor of Biological Sciences, Professor Nadiya Volodymyrivna Boyko .


Together with leading European colleagues — Professor Godfrey Grech  (University of Malta Medical School) and Dr. Moien Khan  — she developed a key chapter of the book dedicated to innovative diagnostics of dysbiosis and the role of chronic intestinal inflammation in the occurrence of systemic diseases of humanity.


The official international release of the book is scheduled for October 14, 2026 , but the publication is already available for pre-order on global platforms today. In this detailed article, we will delve into the details of this unique work, analyze the scientific concept presented by Professor Nadia Boyko, and find out how Ediens is already implementing this advanced world knowledge into real medical practice for Ukrainians.



Two years of hard work: Synergy of 65 scientists from around the world


The creation of a book of this scale was the result of more than two years of coordinated work by 65 leading scientists and clinicians from different parts of the world . The publication combines 21 peer-reviewed chapters , each of which has undergone a rigorous multi-stage audit by independent experts. The main goal of the work was not simply to summarize existing knowledge, but to provide the global medical community with clear, evidence-based protocols for the prevention and reversal of chronic degenerative diseases through lifestyle modification.

The publication examines in detail the key pillars of “Lifestyle Medicine”:

  • Personalized nutrition and nutrigenomics : how different nutrients interact with the human genome and its microbiome, modeling metabolic pathways.

  • Physical activity and mitochondrial health : molecular mechanisms of the effect of sports on reducing systemic inflammation.

  • Sleep hygiene and circadian rhythms : the role of melatonin and sleep in renewing the body's protective barriers.

  • Psychosomatics, stress resistance and social connections : how chronic psychological stress destroys physiological repair systems and changes the composition of the microflora.

  • The microbiome as a central regulator of health : analyzing the interaction between trillions of bacteria and the host immune system.

The editor-in-chief of the series is Professor Olga Golubnitschaja  , President of the European Association for Predictive, Preventive and Personalised Medicine (EPMA, Brussels) . It is under her leadership that the Advances in Predictive, Preventive and Personalised Medicine series  has become an authoritative global platform for publishing breakthrough biomedical technologies that are shaping the healthcare paradigm of the 21st century.


Contribution of Professor Nadiya Boyko: Intestinal dysbiosis and chronic inflammation as hidden triggers of diseases of civilization

The chapter, written by Professor Nadia Boyko in collaboration with Professor Godfrey Grech and Dr. Moien Khan, reveals detailed molecular and immunological mechanisms of how intestinal imbalance becomes a trigger for the development of most known chronic pathologies.


1. The phenomenon of subclinical low-grade inflammation (Low-Grade Inflammation)


Traditional medicine is accustomed to diagnosing inflammation when it is clearly expressed (for example, acute colitis, pancreatitis or infection). However, science proves that the most dangerous is long-term, hidden, asymptomatic chronic inflammation of low intensity . Its initiator is almost always a violation of the permeability of the intestinal barrier, known as the "leaky gut" syndrome  . The intestinal wall is covered with a thin single-layer epithelium and a protective gel of mucin, which normally does not allow large molecules and bacterial components to enter the internal environment of the body.


In dysbiosis (reduction in the diversity of beneficial bacteria and excessive growth of opportunistic microbes), the protective biofilm is destroyed. Bacterial endotoxins — primarily lipopolysaccharides (LPS) , which are components of the cell walls of gram-negative bacteria — begin to massively penetrate through the epithelium into the bloodstream. This process, called metabolic endotoxemia, activates immune cells in the blood, causing them to constantly secrete pro-inflammatory cytokines (interleukin-1β (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α)). The body finds itself in a state of permanent systemic inflammation, which gradually destroys blood vessels, joints, nerve cells, and tissues of internal organs.




2. The microbiome chain: from the gut to the heart, brain and blood vessels


The section analyzes in detail the cause-and-effect relationships between the state of the microbiota and specific nosologies:

  • Metabolic syndrome and obesity : An imbalance between the Firmicutes  and Bacteroidetes bacteria  dramatically alters energy metabolism. Certain microorganisms are able to break down complex carbohydrates too efficiently, leading to excessive calorie absorption even with a moderate diet.

  • Type 2 diabetes : Loss of specific protective bacteria (e.g., butyrate-producing bacteria and mucin-degrading Akkermansia muciniphila ) disrupts insulin receptor signaling pathways, provoking insulin resistance.

  • Cardiovascular risks and atherosclerosis : Professor Boyko's research has shown a clear correlation between the presence of certain transient bacteria in the intestine (for example, Proteus vulgaris  in high concentrations) and a sharp increase in cholesterol and uric acid levels and a drop in secretory immunoglobulin A (sIgA) in the intestine, which accelerates vascular calcification and sclerotization.

  • Neurodegenerative diseases and depression : Through the Gut-Brain Axis, bacteria directly modulate the nervous system. Dysbiosis blocks the synthesis of serotonin and GABA, which exacerbates anxiety, panic attacks, Parkinson's disease, and dementia.


3. Revolutionary methods of diagnosis and therapy


The authors of the section emphasize that treating these conditions with random probiotics “blindly” is ineffective and dangerous. Science requires a precise definition of the etiology of dysbiosis.

Instead of outdated cultures for dysbiosis, the book describes the use of next-generation sequencing (NGS)  16S rRNA technologies and metagenomic analysis of bacterial DNA, which allows for the detection of species diversity (Shannon index), enterotype, and metabolic potential of microflora.


Only with such a detailed picture can the concept of targeted microbiome correction be applied  using an individualized nutrition plan and pharmabiotics  —biological drugs whose therapeutic effects on specific biomarkers of inflammation and immunity have been rigorously clinically proven.


From theory to practice: how Ediens implements the principles of 3P medicine in Ukraine


The main value of Professor Nadiya Boyko's fundamental scientific works is that they do not remain a theory on the pages of foreign tomes. The Ukrainian biotechnology company Ediens was created precisely to transfer these advanced achievements of world science directly to the end consumer and practicing physician.


Today, Ediens is successfully implementing unique services and products in Ukraine that fully comply with the principles of the new Springer Nature book:

  1. BioCode4U diagnostic platform : Ediens does not use template approaches. Each patient undergoes a comprehensive analysis, which includes genetic analysis of the microbiome (NGS sequencing based on leading domestic and European laboratories), advanced blood biochemistry and analysis of inflammatory markers (sIgA, cytokines).

  2. Mathematical modeling and IT algorithms : Using proprietary software EdiensUniCode™ (BioQuantum) , developed jointly by mathematicians and biologists, patient data is digitized. The algorithm compares over 70 individual parameters to determine personal norms and identify hidden risks long before clinical manifestations of the disease.

  3. Personalized nutrition plan : Based on the microbiome analysis, the patient receives an individual diet. Our body is not able to independently absorb all the biologically active substances (BAS) of plants - our bacteria do it. The algorithm selects local foods and drinks (for example, those rich in specific polyphenols and prebiotic fibers) that will be the ideal “food” for your beneficial microflora, excluding those products that will provoke fermentation and bloating.

  4. Niche Evidence-Based Pharmabiotics : Ediens does not produce mass-produced dietary supplements. Each product of the company (for example, the lines “My Second Brain” , “Metabolic Antistress” , “ProfiLactOr” ) was created during 3–4 years of cohort clinical studies on specific groups of patients and is protected by patents. Ediens pharmabiotics have a high concentration and an accurate, verified composition of strains that have been deposited in European collections and are guaranteed to restore damaged mucosa and relieve chronic inflammation.

  5. National social projects : A vivid example of the practical application of 3P medicine is the “Speedy Recovery of Heroes” program , within the framework of which Ediens conducts comprehensive physiological rehabilitation of wounded soldiers of the Armed Forces of Ukraine and patients with PTSD using intestinal microbiome modeling and the use of unique patented psychobiotics (in particular, the drug DefendeX™ ).


Why is this event a historic triumph for Ukrainian science?


The publication of a book by Springer Nature  with the participation of a Ukrainian scientist is a powerful signal to the world community: Ukrainian science is alive, innovative, and at the forefront of global medical progress. Despite war, shelling, power blackouts, and daily difficulties, our scientists continue to create technologies that determine the development of world medicine for decades to come.

This book will become a desktop guide for thousands of practicing physicians, nutritionists, dietitians, and biohackers around the world. It provides a clear understanding: our health is not determined solely by genes or chance—it is the result of the delicate ecological balance of our microbiome, which we can and must consciously and precisely adjust through lifestyle medicine and personalized technology.


Book release and how to pre-order


The official international publication of the book "The Impact of Lifestyle Medicine on Chronic Disease Prevention, Reversal and Management" is scheduled for October 14, 2026. However, to become one of the first owners of this invaluable source of knowledge, you can pre-order it today.

Use the official links to order the book and read its contents:

👉 PRE-ORDER THE BOOK ON AMAZON  — pre-order the print or electronic edition right now.

👉 OFFICIAL BOOK PAGE ON SPRINGER NATURE  — check out the full list of chapters, authorship, and scientific abstracts on the publisher's official website.

Invest in the knowledge that shapes the future of humanity and transform your approach to health with Ediens' world-class science and technology! 🇺🇦🔬



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